|
| 產地 | 廣州 |
| 品牌 | Tanshtech |
| 貨號 | N/A |
| 用途 | 科學研究 |
| 包裝規(guī)格 | 100mg |
| CAS編號 | 1392278-76-0 |
| 純度 | 95% |
| 是否進口 | 否 |
腫liu靶向肽 iRGD peptide環(huán)肽 1392278-76-0 c(CRGDKGPDC)
【中文名稱】
RGD環(huán)肽
【英文名稱】
c(CRGDKGPDC)，iRGD peptide
【CAS】
1392278-76-0
【單字母】
H2N-CRGDKGPDC-OH(Disulfide Bridge:C1-C9)
【三字母】
H2N-Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys-COOH(Disulfide Bridge:Cys1-Cys9)
【氨基酸個數(shù)】
9
【分子式】
C35H57N13O14S2
【平均分子量】
948.04
【 分子量】
947.36
【等電點(PI)】
8.83
【pH=7.0時的凈電荷數(shù)】
1.91
【平均親水性】
1.6666666666667
【疏水性值】
-1.42
【外觀與性狀】
粉末狀固體
【體內研究】
iRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice[1]. iRGD (4 mmol/kg, i.v.) in combination with 5-FU significantly suppresses the tumor growth in nude mice bearing human gastric cancer cells[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
【體外研究】
iRGD peptide-mediated tumor penetration occurs in three steps: binding to αv-integrins on tumor vasculature or tumor cells, exposure by proteolysis of a C-terminal motif that binds to neuropilin-1 (NRP-1) and cell internalization. iRGD peptide inserted in the ICOVIR15K fiber C terminus enhances binding and internalization only in MCF7 cells, which express NRP-1 and integrins. iRGD insertion does not impair virus infection and replication[1]. iRGD peptide alone has no obvious effect on gastric cancer cells, and when combined with 5-FU, iRGD peptide (0.3 μmol/mL) enhances the chemotherapy efficacy of 5-FU on gastric cancer cells through NRP1[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
【產品簡介】
iRGD (CRGDKGPDC) (Disulfide bridge: C1-C9)是一種由 9 個氨基酸組成的二硫鍵環(huán)肽，由 位半胱氨酸C與末尾的C巰基之間氧化形成二硫鍵。它能夠與整合素結合后酶解產生 CRGDK ，再與 神經纖毛蛋白-1 (neuropilin-1) 相互作用，從而促進藥物的組織滲透，具有靶向腫liu以及腫liu滲透的作用。
iRGD和DSPE-PEG偶聯(lián)后，DSPE-PEG-iRGD可以用來制作膠束，囊泡等納米顆粒；iRGD-PEG-DSPE形成的脂質體可以直接作用于腫liu靶點，形成主動靶向效果。
